NK cells in immunotolerant organs

Immunotolerant Properties of Mesenchymal Stem Cells: Updated Review

Stem cell transplantation is a potential therapeutic option to regenerate damaged myocardium and restore function after infarct. Current research is focused on the use of allogeneic mesenchymal stem cells (MSCs) due to their unique immunomodulatory characteristics and ability to be harvested from young and healthy donors. Both animal and human studies support the immunoprivileged state of MSCs ...

Activating natural killer (NK) cytotoxicity of canine CD5−CD21− cells requires low surface CD5 density NK cells

Natural killer (NK) cells play a crucial role in regulating immune functions. Few studies have characterized canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes (PBLs) with a low surface CD5 density (CD5lo) are considered a critical NK population. Natural killer cells in most mammals do not express T-cell markers, but canine CD5lo cells express surface molecules...

NK Cells in Sarcoidosis

The question of whether the initial eosinophilia in case 2 of our report could have been due to Aspergillus infection, perhaps allergic bronchopulmonary Aspergillus (ABPA), can be answered with reasonable certainty. In our opinion the patient did not have specific evidence for the diagnosis of an Aspergillus infection. Cultures for clinically significant Aspergillus are identified in two to six...

NK Cells in HIV Disease

Natural killer (NK) cells play a critical role in viral immunity. In the setting of HIV infection, epidemiologic and functional evidence support a role for NK cells in both protection from new infection and in viral control. Specifically, NK cells directly mediate immune pressure leading to virus evolution, and NK cell receptor genotypic profiles, clonal repertoires, and functional capacity hav...

NK cells in liver disease